| Day 2 |
Monday, December 5th |
| 8:30 - 10:30 |
Session 1 - GPCR structure I |
Martin Caffrey, Chair |
|
Structural insights into the mechanism of G protein coupled receptor activation |
Brian Kobilka, Stanford, USA |
|
Molecular Electron Microscopy of Signaling Receptor Complexes |
Georgios Skiniotis, University of Michigan, USA |
|
Transient signaling complexes and GPCR dimers |
Nevin Lambert, Georgia Health Sciences University, USA |
| 10:30 - 11:00 |
Tea break |
| 11:00 - 13:00 |
Session 2 - GPCR structure II |
Leonardo Pardo, Chair |
|
Structural mechanisms of chemokines and chemokine receptors |
Tracy Handel, University of California, San Diego, USA |
|
Structure and dynamics of rhodopsin |
Oliver Ernst, University of Toronto, Canada |
|
Structure ad function of muscarinic acetylcholine receptor |
Tatsuya Haga |
| 13:00 - 15:30 |
Lunch and posters |
Poster viewing time will be between 14:00 to 15:30 |
| 15:30 - 19:30 |
Free time |
Preparation for interactive discussion session |
| 19:30 - 21:30 |
Session 3 - Interactive discussion |
|
| Day 3 |
Tuesday, December 6th |
| 8:30 - 10:30 |
Session 4 - GPCR structure and drug discovery |
Larry Miller, Chair |
|
Single molecule imaging of GPCR dimerization in living cells |
Jonathan Javitch, Columbia University, USA |
|
Folding and forward trafficking of GPCRs; a target for drug discovery |
Michel Bouvier, University of Montreal, Canada |
|
Activation of G protein by monomeric class C metabotropic glutamate receptor |
Sebastien Granier - Montpeliier University/INSERM/Stanford University |
| 10:30 - 11:00 |
Tea break |
|
| 11:00 - 13:00 |
Session 5 - Membrane biophysics and GPCR function |
Roger Sunahara, Chair |
|
Effect of lipid structure on membrane protein function |
Cedric Govaerts, Free University, Brussels, Belgium |
|
Cholecystokin receptors, lipid interaction and obesity |
Larry Miller, Mayo Clinic, Scottsdale, USA |
|
Effect of membrane curvature on membrane protein function |
Dimitrios Stamou, University of Copenhagen, Denmark |
| 13:00 - 15:30 |
Lunch and posters |
Poster viewing time will be between 14:00 to 15:30 |
| 15:30 - 19:30 |
Free time |
Preparation for interactive discussion session |
| 16:00 - 18:00 |
Mini-workshop "Crystallizing membrane proteins in lipidic mesophases"
* For details, please see below, at the end of the schedule. |
Martin Caffrey, Trinity College, Dublin, Ireland |
| 19:30 - 21:30 |
Session 6 - Interactive Discussion |
|
| Day 4 |
Wednesday, December 7th |
| 8:30 - 10:30 |
Session 7 - Chemical genomics |
Michel Bouvier, Chair |
|
GPCRs: from sequence to structure and back, what have we learned |
Tara Mirzadegan, Johnson & Johnson, USA |
|
Accounting for target flexibility in drug discovery: GPCRs |
Andrew McCammon, University of California, San Diego, USA |
|
Discovering endogenous and exogenous ligands for orphan GPCRs via large-scale parallel profiling |
Bryan Roth, University of North Carolina, USA |
| 10:30 - 11:00 |
Tea break |
|
| 11:00 - 12:20 |
Session 8 - Molecular modelling of GPCRs |
Andrew McCammom, Chair |
|
Computational methods in drug design. New approaches for GPCR modulation |
Leo Pardo, Universitat Autònoma de Barcelona, Spain |
|
Revealing the atomic-level mechanisms of GPCR activation and drug binding through long-timescale simulation |
Ron Dror, D. E. Shaw Research, USA |
| 12:20 - 14:00 |
Lunch |
|
| 14:00 - 15:20 |
Session 9 - Screening technologies |
Thue Schwartz, Chair |
|
Receptor biology and ligand pharmacology in a label-free world |
Ye Fang, Corning, USA |
|
Advanced GPCR Modelling enables Fragment Aided Drug Design for GPCRs; Bradykinin and Histamine Receptor examples. |
Richard Law, Evotec |
| 15:20 - 17:00 |
Free time |
Preparation for interactive discussion session |
| 17:00 - 19:30 |
Session 10 - Interactive discussion |
|
| 20:00 - late |
Conference banquet |
|
| Day 5 |
Thursday, December 8th |
| 9:00 - 10:20 |
Session 11 - Ligand-directed signaling |
Patrick Sexton, Chair |
|
Impact of GPCR phosphorylation on physiological responses |
Andrew Tobin, University of Leicester, United Kingdom |
|
Structure - knowledge-based discovery of small molecule ligands for 7TM
receptors - from pocket to compounds without chemical synthesis |
Thue Schwartz, University of Copenhagen, Denmark |
| 10:20 - 11:00 |
Tea break |
|
| 11:00 - 12:20 |
Session 12 - In vivo validation |
Andrew Tobin, Chair |
|
TGR5: A GPCR target for cholestatic and metabolic diseases? |
Nigel Bunnett, Monash Institute of Pharmaceutical Sciences, Australia |
|
GPCR signaling and neurodegenerative diseases |
Gang Pei, SIBS and Tongji University, China |
| 12:20 - 14:00 |
Lunch |
|
| 14:00 - 15:20 |
Session 13 - Structural basis for allosteric receptor modulation |
Arthur Christopoulos, Chair |
|
Towards understanding modes of allosteric ligand-GPCR interaction |
Rob Lane, Monash University, Australia |
|
Structure-function studies of allosteric modulation at the muscarinic acetylcholine receptors |
Klaus Mohr, University of Bonn, Germany |
| 15:20 - 16:00 |
Discussion & close |
|
