GPCR Workshop Agenda Dec 1 — 5, 2019, Big Island of Hawaii

Preliminary Program - Sessions and Topics:


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Day 1 Sunday, December 1st
14:00 - 15:50 Registration
15:50 - 16:00 Welcome Brian Kobilka, Chair, Stanford University, CA USA
16:00 - 16:50 Molecular Puzzles in Hedgehog Signaling Aashish Manglik, UCSF, CA USA
16:50 - 17:30 Mechanisms of Frizzled Receptor Signaling Bill Weis, Stanford University, CA USA
17:30 - 18:30 Keynote Lecture - Receptors to Behavior Charles Zuker, Columbia University, NYC USA
18:30 Welcome Reception  

Day 2 Monday, December 2nd
Session 1 Computational Methods  
8:30 - 9:10 Data Science Approaches to GPCR Signaling M. Madan Babu, MRC Cambridge UK
9:10 - 9:50 Understanding How to Fine-Tune muOpiod Receptor Signaling Towards the Discovery of Safer Analgesics Marta Filizola, Mt. Sinai, NYC USA
9:50 - 10:30 Structural and Functional Diversity of GPCR Oligomers Leonardo Pardo, University of Barcelona, Spain
10:30 - 11:00 Break  
Session 2 Drug Discovery  
11:00 - 11:40 Molecular Simulation for the Design of Finely Tuned GPCR-targeted Drugs Ron Dror, Stanford University, USA
11:40 - 12:20 Structural Biology of Class B GPCRs - A Ligand and Pharma Perspective Steffen Reedtz-Runge, Novo Nordisk, Denmark
12:20 - 13:00 Structure and Pharmacology of Lipid GPCRs in Asthma Cheng Zhang, University of Pittsburgh, PA USA
13:00 - 15:30 Lunch and Poster Viewing  
15:30 - 19:00 Free Time and Preparation for Interactive Discussion Session
19:00 - 22:00 Interactive Discussion Chair, Brian Kobilka

Day 3 Tuesday, December 3rd
Session 3 GPCR Structure and Dynamics 1 Chair, Patrick Sexton
8:30 - 9:10 Newer GPCR56 Modulators to Probe Adhesion GPCR Activation Mechanisms Greg Tall, University of Michigan, USA
9:10 - 9:50 Unraveling the Molecular Basis of Biased Agonism at class B GPCRs Denise Wootten, Monash University, Australia
9:50 - 10:30 Decoding G-protein Coupling Selectivity with a Large Functional Dataset Asuka Inoue, Tohoku University, Japan
10:30 - 11:00 Break  
Session 4 Signaling and Physiology 1 Chair, Arthur Christopoulos
11:00 - 11:40 GPCR Signaling from Internal Membrane Compartments Roshanak Irannejad, UCSF, CA USA
11:40 - 12:20 Intracellular GPCRs Play Key Roles in Vivo Karen O’Malley, Washington University School of Medicine, St. Loius, USA
12:20 - 13:00 Conventional and Unconventional Receptor-G Protein Coupling Nevin Lambert, Medical College of Georgia, USA
13:00 - 15:30 Lunch  
15:30 - 19:00 Free Time and Preparation for Interactive Discussion Session
19:00 - 22:00 Interactive Discussion Arthur Christopoulos

Day 4 Wednesday, December 4th
Session 5 GPCR Structure and Dynamics 2 Chair, Denise Wootten
8:30 - 9:10 Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated to a Bacterial Expression Host Laurent Catoire, Universite de Paris, Paris France
9:10 - 9:50 The Structure and Function of Alkaline Ceramidase 3 are Related to Adiponectin Receptors Sebastien Granier, University of Montpellier, France
9:50 - 10:30 Structural Basis for KCTD-mediated Rapid Desensitization of GABAB Receptor Signaling Andy Kruse, Harvard University, Cambridge, MA USA
10:30 - 11:00 Break  
Session 6 Signaling and Physiology 2  
11:00 - 11:40 Leveraging Functional Selectivity/Biased Signaling at GPCRs for Therapeutic Benefits Marc Caron, Duke University, North Carolina USA
11:40 - 12:20 Illuminating the “Dark Matter” of the Gut Microbiota Metabolome Noah Palm, Yale University, CT USA
12:20 - 13:00 The Expanded RAMP Interactome Kathleen Caron, UNC USA
13:00 - 15:30 Lunch  
15:30 - 18:00 Interactive Session Denise Wootten
18:30 Sunset Dinner/Banquet

Day 5 Thursday, December 5th
Session 7 Potpourri Brian Kobilka
9:30 - 10:10 Density-dependent Mu Opioid Receptor Function Revealed by Single-molecule Tracking Jonathan Javitch, Columbia University, NYC USA
10:10 - 10:50 TBD TBD
10:50 - 11:40 TBD TBD
11:40 - 12:00 Closing Remarks by Organizers  


Chat Board for Attendees

If you want to coordinate transportation, discuss room sharing or other topics for the seminar, please visit the chat board we have set up for our attendees, GPCR Workshop Chat Board